[Loke]

Yeh, for an example on the Overlord level you have to kill a couple of cocooned babes in order to get a few items that's stuck behind them. And on Fusion Station, near the beginning, you have to kill a cocooned babe to get the shotgun behind her.

Now when I think about it you also have to kill all three cocooned babes in The Abyss level in episode 1 to get all the goodies behind them.