[NightFright]

If you are concerned about crashes or bugs, there are none, at least not gameplay-related. You might encounter some badly aligned models (such as the floating/flipped slime babe in Ep.3), but it's still quite a joy to play through the whole thing.
I recommend using the EDuke32 music mod executable by Hunter_rus so you can also use the OGG soundtrack. Furthermore, you might want to wait with playing till end of November, for I am planning on releasing another HRP Update Pack with some new textures (e.g. the new water and rock textures gt made recently) by then.

I can't tell what kinda machine you should have for running the HRP properly, but minimum should be 2.4-3GHz CPU, 512MB RAM and a decent graphics card (GeForce 5K series with at least 128MB RAM or higher). For comparison, I am running it on a P4/3.0 GHz HT, 2GB RAM, GF 6800 (128MB) in a WinXP SP2 environment. Using Vista will raise requirements, especially concerning graphics card memory (if you use Aero).