Well I'd like to see a few things with Prey2. More twisted and insane environments, especially with a more supernatural feel. Even more Inspiration from Native American mythology, evil spirits, possessions etc. Alien Mythology and supernatural as well. I found levels were a bit too linear, I hope they are made a lot more open. I'm not necessarily talking open ended, just make the level path a lot wider instead of funneling the player down long bottle necks and give us the freedom to explore a bit. I was a little disheartened by the interactivity. It was excellent at the start but it didn't last through the whole game, so some consistency there would be good. More gore please!!!
I loved how you could blow chunks off those slave guys, its a shame that this didn't apply to all enemies. Let us play with the ragdoll bodies. Half the fun with ragdolls are watching them fall down steps or from high places and tumbling around, being able to pick them up and throw them around would be great fun. Finally, it would be fun if Tommy had a spear that he could use as a melee and a projectile weapon.